Endocrine Abstracts

Background: Diabetic ketoacidosis (DKA) is a common presentation of newly diagnosed type 1 diabetes (T1DM) in children but increases the disease burden at diagnosis. In UK, average frequency of DKA presentation is reported as 25% with an international variation of 16 to 67%. Data on frequency variations within the UK is limited.Aim: To compare the demographic and clinical characteristics of DKA vs non-DKA presentations in children <16 years at diagno...

Introduction: The British Society of Paediatric Endocrinology (BSPED) DKA guidelines endorse the use of subcutaneous (SC) insulin in clinically well patients. In our institution, routine practice is to use SC insulin to manage DKA patients, without clinical evidence of shock. We present safety and efficacy data.Methods: A retrospective review of electronic records was performed to identify episodes of DKA (pH <7.30 or HC03<18 mmol/l and ketonaemi...

Introduction: Offspring of mothers with diabetes have greater risk of adverse metabolic outcome in later life. Increased adiposity is a plausible mediator. We performed a meta-analysis of studies examining adiposity in infants and children in relation to maternal diabetes.Methods: Citations were identified in PubMed and authors contacted for additional data. Fat free mass, fat mass, body fat %, and skinfold thickness were compared in offspring of mothers...